Friday, July 3, 2015

Honey Bee Products Improve the Immune System

Yet another synergistic effect from consuming bee products. This is an important update to a previous study that identified lactic acid bacteria present in honey, bee pollen and bee bread. This human trial, even though small, reveals great promise for those needing immune system support, complementing the medical community's interest in the connection between the immune system and a healthy gut.

Lactobacillus kunkeei YB38 from honeybee products enhances IgA production in healthy adults
J Appl Microbiol. 2015 Jun 29. doi: 10.1111/jam.12889.

To identify lactic acid bacterial isolates that promote IgA production in honeybee products and honeybees (Apis mellifera).

Pyrosequencing analysis of the microbiota of honeybee products and honeybees revealed the predominance of Lactobacillus kunkeei in honey, bee pollen, bee bread, and royal jelly. L. kunkeei was isolated from bee pollen, bee bread, and honey stomach, and its effect on IgA production was evaluated in vitro. Heat-killed YB38 and YB83 isolates from bee pollen promoted IgA production in mouse Peyer's Patch cells and had little mitogenic activity or effect on IL-2 production in mouse spleen cells in comparison with Listeria monocytogenes, which does exhibit mitogen activity. A pilot study in 11 healthy adults showed that 4-week intake of 1,000 mg/day heat-killed YB38 increased SIgA concentrations and secretion in saliva with no adverse effects.

Heat-killed L. kunkeei YB38 from bee pollen increases IgA production and may safely improve immune responsiveness.

This is the first report of microbiota analysis of royal jelly and the immune efficacy of L. kunkeei from honeybee products in humans.

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