Propolis speeds up the healing process and stimulates collagen development. This study clearly shows a big advantage in using propolis in place of surgical creams...
Effect of
Topical Application of Different Substances on Fibroplasia in Cutaneous
Surgical Wounds
ISRNDermatol, 2012
Background:
Fibroblasts on the edges of a surgical wound are induced to synthesize collagen
during the healing process which is known as fibroplasia.
Objective:
The aim of this study was to determine the effect of the application of
different substances on fibroplasia of cutaneous surgical wounds on rats.
Materials
and Methods:
48 Wistar rats were divided into three groups. A surgical wound
1 cm in diameter and 1 mm in depth was created on the dorsum of each animal.
The surgical wounds were submitted to the topical application of an alcoholic
extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base
every 12 hours. The animals were sacrificed three, seven, 14, and 28 days
postoperatively. The specimens were histologically processed and stained with
Masson's trichrome. The assessment of fibroplasia was performed using a scoring
system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition;
(3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition.
Results:
There
were statistically significant differences in collagen deposition between the
substances at all postoperative evaluation times.
Conclusion:
Propolis and alcohol promoted greater collagen deposition in surgical wounds
than dexamethasone.
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